Q&A: Elizabeth Blackburn on telomerase and tumors.
نویسنده
چکیده
“More and more of us are thinking that the way we really get rid of this problem of resistance to targeted cancer drugs is to actually kill the cells, as opposed to throttling them down,” says Elizabeth Blackburn, PhD, professor of biology and physiology at the University of California, San Francisco, and a 2009 Nobel laureate. “From that point of view, there’s a lot of life in research on interfering with telomeres.” Blackburn discussed research on these regions of repetitive DNA at chromosome ends, and related strategies to treat or delay cancer, with Cancer Discovery’s Eric Bender.
منابع مشابه
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions.
The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote the chromosome-stabilizing properties of telomeres are discussed here.
متن کاملTelomerase and Cancer
Telomerase is commonly expressed in human cancer cells. Increased telomerase expression produces vulnerability of cancer cells, distinguishing them from normal cells in the body, although normal cells do also have some active telomerase. Recent studies also suggest that telomerase is implicated in tumor progression in unexpected ways. These observations lead us to investigate the most efficient...
متن کاملEarly Work on Telomeres
The DNA sequence of Tetrahymena telomeres was the first to be determined among all telomeres by Elizabeth Blackburn and Joseph Gall in 1978. In 1982, Jack Szostak and Blackburn showed that the unique DNA sequence contained in the telomeres served to protect the chromosomes from degradation. In 1985, Carol Greider and Blackburn showed how the telomeres could be elongated by the enzyme telomerase...
متن کاملAn overview on the role of telomere, telomerase in degenerative diseases and cancer
Telomerase maintains the length of telomeric DNA at the end of chromosomes; stabilizes the functions of chromosomes, protects the structure of chromosome DNA and regulates normal cell growth. The length and stability of telomeres determine the cellular lifespan. Moreover, they correlate with cellular aging and carcinogenesis. Researches on the role of telomerase in degenerative diseases and can...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer discovery
دوره 3 12 شماره
صفحات -
تاریخ انتشار 2013